Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

In vivo CD8⁺ T cell CRISPR screening reveals control by Fli1 in infection and cancer.

Chen, Zeyu; Arai, Eri; Khan, Omar; Zhang, Zhen; Ngiow, Shin Foong; He, Yuan; Huang, Hua; Manne, Sasikanth; Cao, Zhendong; Baxter, Amy E; Cai, Zhangying; Freilich, Elizabeth; Ali, Mohammed A; Giles, Josephine R; Wu, Jennifer E; Greenplate, Allison R; Hakeem, Mohamed A; Chen, Qingzhou; Kurachi, Makoto; Nzingha, Kito; Ekshyyan, Viktoriya; Mathew, Divij; Wen, Zhuoyu; Speck, Nancy A; Battle, Alexis; Berger, Shelley L; Wherry, E John; Shi, Junwei.

Cell ; 184(5): 1262-1280.e22, 2021 03 04.

Artigo em Inglês | MEDLINE | ID: mdl-33636129

2.

RUNX1 is required in granulocyte-monocyte progenitors to attenuate inflammatory cytokine production by neutrophils.

Zezulin, Alexandra U; Yen, Daniel; Ye, Darwin; Howell, Elizabeth D; Bresciani, Erica; Diemer, Jamie; Ren, Jian-Gang; Ahmad, Mohd Hafiz; Castilla, Lucio H; Touw, Ivo P; Minn, Andy J; Tong, Wei; Liu, P Paul; Tan, Kai; Yu, Wenbao; Speck, Nancy A.

Genes Dev ; 37(13-14): 605-620, 2023 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-37536952

3.

Hematopoietic stem cell arrival triggers dynamic remodeling of the perivascular niche.

Tamplin, Owen J; Durand, Ellen M; Carr, Logan A; Childs, Sarah J; Hagedorn, Elliott J; Li, Pulin; Yzaguirre, Amanda D; Speck, Nancy A; Zon, Leonard I.

Cell ; 160(1-2): 241-52, 2015 Jan 15.

Artigo em Inglês | MEDLINE | ID: mdl-25594182

4.

Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML.

Riedel, Simone S; Lu, Congcong; Xie, Hongbo M; Nestler, Kevin; Vermunt, Marit W; Lenard, Alexandra; Bennett, Laura; Speck, Nancy A; Hanamura, Ichiro; Lessard, Julie A; Blobel, Gerd A; Garcia, Benjamin A; Bernt, Kathrin M.

Mol Cell ; 81(11): 2332-2348.e9, 2021 06 03.

Artigo em Inglês | MEDLINE | ID: mdl-33974912

5.

Efficient hemogenic endothelial cell specification by RUNX1 is dependent on baseline chromatin accessibility of RUNX1-regulated TGFß target genes.

Howell, Elizabeth D; Yzaguirre, Amanda D; Gao, Peng; Lis, Raphael; He, Bing; Lakadamyali, Melike; Rafii, Shahin; Tan, Kai; Speck, Nancy A.

Genes Dev ; 35(21-22): 1475-1489, 2021 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-34675061

6.

Macrophages Fertilize the Soil to Promote Hematopoietic Cell Growth.

Bennett, Laura; Mumau, Melanie; Speck, Nancy A.

Immunity ; 50(6): 1342-1344, 2019 06 18.

Artigo em Inglês | MEDLINE | ID: mdl-31216456

7.

Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells.

Gao, Peng; Chen, Changya; Howell, Elizabeth D; Li, Yan; Tober, Joanna; Uzun, Yasin; He, Bing; Gao, Long; Zhu, Qin; Siekmann, Arndt F; Speck, Nancy A; Tan, Kai.

Genes Dev ; 34(13-14): 950-964, 2020 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-32499402

8.

MyD88-dependent TLR signaling oppositely regulates hematopoietic progenitor and stem cell formation in the embryo.

Bennett, Laura F; Mumau, Melanie D; Li, Yan; Speck, Nancy A.

Development ; 149(8)2022 04 15.

Artigo em Inglês | MEDLINE | ID: mdl-35043940

9.

Endothelial MEKK3-KLF2/4 signaling integrates inflammatory and hemodynamic signals during definitive hematopoiesis.

Yang, Yiqing; Mumau, Melanie; Tober, Joanna; Zhu, Qin; Bennett, Laura; Hong, Courtney; Sung, Derek; Keller, Thomas; Uzun, Yasin; Gao, Peng; Shewale, Swapnil; Chen, Mei; Yang, Jisheng; Chen, Xiaowen; Thomas, Steven A; Tan, Kai; Speck, Nancy A; Kahn, Mark L.

Blood ; 139(19): 2942-2957, 2022 05 12.

Artigo em Inglês | MEDLINE | ID: mdl-35245372

10.

Conversion of adult endothelium to immunocompetent haematopoietic stem cells.

Lis, Raphael; Karrasch, Charles C; Poulos, Michael G; Kunar, Balvir; Redmond, David; Duran, Jose G Barcia; Badwe, Chaitanya R; Schachterle, William; Ginsberg, Michael; Xiang, Jenny; Tabrizi, Arash Rafii; Shido, Koji; Rosenwaks, Zev; Elemento, Olivier; Speck, Nancy A; Butler, Jason M; Scandura, Joseph M; Rafii, Shahin.

Nature ; 545(7655): 439-445, 2017 05 25.

Artigo em Inglês | MEDLINE | ID: mdl-28514438

11.

CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation.

Hsu, Jingmei; Huang, Hsuan-Ting; Lee, Chung-Tsai; Choudhuri, Avik; Wilson, Nicola K; Abraham, Brian J; Moignard, Victoria; Kucinski, Iwo; Yu, Shuqian; Hyde, R Katherine; Tober, Joanna; Cai, Xiongwei; Li, Yan; Guo, Yalin; Yang, Song; Superdock, Michael; Trompouki, Eirini; Calero-Nieto, Fernando J; Ghamari, Alireza; Jiang, Jing; Gao, Peng; Gao, Long; Nguyen, Vy; Robertson, Anne L; Durand, Ellen M; Kathrein, Katie L; Aifantis, Iannis; Gerber, Scott A; Tong, Wei; Tan, Kai; Cantor, Alan B; Zhou, Yi; Liu, P Paul; Young, Richard A; Göttgens, Berthold; Speck, Nancy A; Zon, Leonard I.

Proc Natl Acad Sci U S A ; 117(38): 23626-23635, 2020 09 22.

Artigo em Inglês | MEDLINE | ID: mdl-32883883

12.

Developmental trajectory of prehematopoietic stem cell formation from endothelium.

Zhu, Qin; Gao, Peng; Tober, Joanna; Bennett, Laura; Chen, Changya; Uzun, Yasin; Li, Yan; Howell, Elizabeth D; Mumau, Melanie; Yu, Wenbao; He, Bing; Speck, Nancy A; Tan, Kai.

Blood ; 136(7): 845-856, 2020 08 13.

Artigo em Inglês | MEDLINE | ID: mdl-32392346

13.

Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production.

Li, Yan; Esain, Virginie; Teng, Li; Xu, Jian; Kwan, Wanda; Frost, Isaura M; Yzaguirre, Amanda D; Cai, Xiongwei; Cortes, Mauricio; Maijenburg, Marijke W; Tober, Joanna; Dzierzak, Elaine; Orkin, Stuart H; Tan, Kai; North, Trista E; Speck, Nancy A.

Genes Dev ; 28(23): 2597-612, 2014 Dec 01.

Artigo em Inglês | MEDLINE | ID: mdl-25395663

14.

Runx1 is sufficient for blood cell formation from non-hemogenic endothelial cells in vivo only during early embryogenesis.

Yzaguirre, Amanda D; Howell, Elizabeth D; Li, Yan; Liu, Zijing; Speck, Nancy A.

Development ; 145(2)2018 01 29.

Artigo em Inglês | MEDLINE | ID: mdl-29361566

15.

A Pernicious Cycle Affecting Premalignant Stem Cells.

Speck, Nancy A.

N Engl J Med ; 386(6): 596-598, 2022 Feb 10.

Artigo em Inglês | MEDLINE | ID: mdl-35139279

16.

Of lineage and legacy: the development of mammalian hematopoietic stem cells.

Dzierzak, Elaine; Speck, Nancy A.

Nat Immunol ; 9(2): 129-36, 2008 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-18204427

17.

Tyrosyl phosphorylation toggles a Runx1 switch.

Neel, Benjamin G; Speck, Nancy A.

Genes Dev ; 26(14): 1520-6, 2012 Jul 15.

Artigo em Inglês | MEDLINE | ID: mdl-22802526

18.

Chd7 deficiency delays leukemogenesis in mice induced by Cbfb-MYH11.

Zhen, Tao; Kwon, Erika M; Zhao, Ling; Hsu, Jingmei; Hyde, R Katherine; Lu, Ying; Alemu, Lemlem; Speck, Nancy A; Liu, P Paul.

Blood ; 130(22): 2431-2442, 2017 11 30.

Artigo em Inglês | MEDLINE | ID: mdl-29018080

19.

Extravascular endothelial and hematopoietic islands form through multiple pathways in midgestation mouse embryos.

Yzaguirre, Amanda D; Speck, Nancy A.

Dev Biol ; 415(1): 111-121, 2016 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-27105579

20.

The Role of Runx1 in Embryonic Blood Cell Formation.

Yzaguirre, Amanda D; de Bruijn, Marella F T R; Speck, Nancy A.

Adv Exp Med Biol ; 962: 47-64, 2017.

Artigo em Inglês | MEDLINE | ID: mdl-28299650

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